Use of Linear Ion Traps in Data-Independent Acquisition Methods Benefits Low-Input Proteomics

نویسندگان

چکیده

The need for a better understanding of cellular heterogeneity has pushed mass spectrometry technologies to the analysis single-cell and single-cell-type proteomes, although several challenges still limit their widespread implementation. Among efforts toward low-input analyses, there is adoption data-independent acquisition methods increase analytical sensitivity. Here, we revisited use linear ion traps analyzers in demonstrate benefits boost peptide protein identifications proteomes.

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ژورنال

عنوان ژورنال: Analytical Chemistry

سال: 2021

ISSN: ['1520-6882', '0003-2700']

DOI: https://doi.org/10.1021/acs.analchem.1c01885